What Causes Low Globulin Levels?

Low globulin levels can indicate that someone is suffering from autoimmune disease, cirrhosis, kidney disease or multiple myeloma, according to Healthline. Doctors use a total protein test to measure globulin levels.

The total protein test measures the presence of globulin and albumin in the body. Usually, there is a slightly higher ratio of albumin to globulin. When protein levels overall are low, rather than just globulin, doctors may screen for:

  • Liver or kidney disorders
  • Bleeding
  • Malnutrition or malabsorption conditions
  • Severe or extensive burns
  • Agammaglobulinemia

The total protein test does not provide a definitive diagnosis. Instead, doctors use further diagnostic tests to determine the cause of low globulin levels.

Health News Channel notes that kidney disease occurs when the body expels globulin and protein through urination. The glomeruli of the kidneys are responsible for filtering protein nutrients and globulin levels. When the glomeruli are suppressed through kidney infection, vital nutrients, such as globulin, are lost.

Globulin also dwells in the red blood cells. Hemolytic anemia occurs when the blood cells die faster than their lifespan of 120 days, and the body fails to produce new blood cells within this period. Globulin decreases as the blood cell count dwindles. Liver disease also kills red blood cells.