Eruptive xanthomatosis, a condition associated with uncontrolled blood glucose levels, causes itchy palms in some diabetics, according to WebMD. Other possible symptoms of eruptive xanthomatosis include itching in other areas, small yellowish lumps on the skin and high cholesterol levels. The condition improves when blood glucose levels are brought back into the normal range. No other treatment is available.
Eruptive xanthomatosis occurs when the level of fat in the bloodstream rises abnormally as a side effect of diabetes, states the American Diabetes Association. Some of this excess fat transfers to the skin causing itchiness and lumps. Itching is most common in the hands and feet. If the condition is severe, small, firm lumps with red halos develop in the affected areas. Eruptive xanthomatosis is most common in male diabetic patients with type 1 diabetes who also have documented high cholesterol levels.
The fatty lumps associated with itchy palms range from pale pink to yellow in color and grow up to the size of a pea, explains MedicineNet. High triglyceride counts are another likely cause, and both diabetic xanthoma and tuberoeruptive xanthoma are alternate names for the condition. Eruptive xanthomatosis is a warning sign of early heart disease. Controlling the condition includes following a diabetes treatment plan and working to reduce blood cholesterol and triglyceride levels.