According to WebMD, high muscle enzyme levels are a possible indicator of inflammatory muscle disease. High levels of muscle enzymes can also be caused by injections into a muscle, muscle disease caused by an underactive thyroid, trauma, and taking certain medications such as cholesterol-lowering drugs.
According to the National Library of Medicine, a blood test is used to check muscle enzyme levels, which are also known as creatine phosphokinase or CPK. The procedure to draw blood is called venipuncture, and it can be repeated over two or three days if performed on a patient in a hospital. The test can be used to diagnose a heart attack, evaluate the cause of chest pain, detect muscle diseases, and to tell the difference between malignant hypothermia and postoperative infection. The test can also be used to assess how badly a muscle is damaged.
The National Library of medicine states that there really is no preparation necessary for the test, but a doctor should be aware of any medications that are currently being taken prior to testing as they can affect levels of muscle enzymes. Some medicines that affect muscle enzyme levels are amphotericin B, some anesthetics, statins, fibrates, alcohol, dexamethasone and cocaine.