What Are the Causes of High Enzyme Levels in a Liver Function Test?

The most common causes of elevated liver enzymes include heart failure, alcohol use, certain prescription and over-the-counter medications, hepatitis and obesity, according to Mayo Clinic. Other causes include celiac disease, cirrhosis, liver cancer, pancreatitis and hypothyroidism. Infectious causes include cytomegalovirus and Epstein-Barr virus infections.

Elevated liver enzymes often appear during the completion of routine blood work and can indicate the presence of damage to or inflammation of the liver, explains Mayo Clinic. Common liver enzymes that blood tests look for include alanine transaminase and aspartate transaminase, which damaged or inflamed liver cells often release into the bloodstream with other chemicals.