Damage to the muscles and liver due to certain medical conditions cause elevated levels of aldolase in the body. Malignant tumors, such as prostrate cancer, chronic leukemia and carcinomas that spread to the liver, may also result in increased aldolase concentrations, notes Mayo Medical Laboratories.
Aldolase functions in the conversion of glucose into energy through catalytic activity. A spike in aldolase levels may indicate the presence of muscular diseases, such as dermatomyositis, limb-girdle dystrophy, polymyositis and Duchenne muscular dystrophy. The most significant increases occur with progressive muscular dystrophy.
A heart attack, medically referred to as myocardial infarction, can severely damage the cardiac muscles and lead to elevated aldolase levels. Liver diseases, such as acute viral hepatitis, portal cirrhosis, obstructive jaundice and chronic hepatitis are also known to raise aldolase concentrations, states Mayo Medical Laboratories.