The main cause of epidermolysis bullosa is genetic inheritance, according to Mayo Clinic. Patients receive faulty genes from one or both of their parents, states the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
Research shows that faulty genes cause the different types of epidermolysis bullosa, explains Mayo Clinic. Inherited types of epidermolysis bullosa include epidermolysis bullosa simplex, junctional epidermolysis bullosa, dystrophic epidermolysis bullosa and Kindler syndrome. These types of epidermolysis bullosa become apparent at birth and in early infancy and childhood.
The cause of epidermolysis bullosa simplex is a faulty fibrous protein that produces keratin, explains Mayo Clinic. Junctional epidermolysis bullosa is as a result of a faulty gene that forms thread-like fibers that attach the epidermis to the basement membrane. A flaw in the gene that produces a type of collagen causes dystrophic epidermolysis bullosa. Kindler syndrome is quite rare and causes blisters across different skin layers.
Epidermolysis bullosa acquisita is a rare type that occurs when the patient's immune system mistakenly attacks healthy tissue, reports the National Institute of Arthritis and Musculoskeletal and Skin Diseases. There have been cases where drug therapy for another condition causes epidermolysis bullosa acquisita. This condition causes blisters on the hands, mucous membranes and feet.