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What are some causes of an elevated CA-125 test?

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An elevated CA-125 test may indicate the presence of ovarian cancer as well as other conditions such as pregnancy, uterine fibroids, endometriosis, pelvic inflammation disease, pancreatitis and liver disease. Elevated CA-125 levels also indicate normal menstruation and benign tumors of the ovaries, according to WebMD.

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The CA-125 test is used most often to determine how successful ongoing treatment is in ovarian cancer patients, rather than as a predictor for the disease itself, according to WebMD. If periodic test results decrease, it is proof that the therapy prescribed is effectively fighting the cancer. Because so many noncancerous conditions can be identified by an elevated CA-125 test, it is not a reliable test by itself for diagnosing cancer.

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