Bright's disease is caused by inflammation on certain parts of the kidneys, typically in the spaces between renal tubules or on the glomeruli, according to WiseGeek. Several conditions can cause this disease to occur, including lupus, urinary tract infections, bacterial infections and certain allergies.
Other possible causes of Bright's disease include pneumonia, mononucleosis, measles and hepatitis, according to WiseGeek. Also, an imbalance of potassium and calcium in the blood can lead to kidney inflammation of this sort. Certain nonsteroidal anti-inflammatory drugs have been known to lead to Bright's disease.
The most common symptoms that patients of Bright's disease report include intense pain on one or both sides of the lower back, fever and nausea, notes WiseGeek. Additionally, patients may observe dark, cloudy or bloody urine.
Several complications associated with Bright's disease are known to occur in some cases, according to WiseGeek. One of the most common complications is nephritic syndrome, where red blood cells and proteins leak into urine through holes in the glomeruli caused by Bright's disease. Improper kidney functioning over time can also lead to metabolic acidosis, a condition marked by an overabundance of acid in the body. In rare cases, complications can lead to kidney failure and end-stage kidney disease, putting patients on permanent dialysis or making transplant necessary.