What Is the Cause and Treatment for Malaise and Fatigue?

Malaise and fatigue have multiple possible causes, and the treatment for these conditions depends on what cause is diagnosed, according to Healthline. Symptoms of malaise and fatigue can be minimized, however, through regular exercise, plenty of rest, controlling stress and a healthy diet.

Fatigue is very often present when a person suffers from malaise, which is a general feeling of illness and discomfort, Healthline says. Malaise and fatigue can be caused by cardiac conditions, cancer, parasites and infectious diseases. Infectious diseases likely to cause malaise include AIDS, pneumonia, bronchitis, mononucleosis and hepatitis. Certain glandular disorders also can cause malaise and fatigue, as can depression. Physical conditions such as anemia, diabetes and rheumatoid arthritis are also possible causes.

Some medications for other conditions can cause malaise as a side effect, according to Healthline. These include beta blockers, anticonvulsants and antihistamines. Because malaise and fatigue have so many possible causes, preventing these symptoms is difficult. When doctors are seeking a cause for the malaise, a full physical exam is done, along with X-rays and blood tests. The history of the patient is also examined, including recent travel, current medications, drug use, alcohol use, existing health issues and any additional symptoms the patient suffers.