What Is the Cause of Insufficient Kidney Function?

The causes of insufficient kidney function include renal artery disease, blood clots, alcohol abuse, heart disease and cirrhosis, according to Healthline. Cholesterol deposits and colon and bladder cancers can also decrease kidney function.

Infections, use of ibuprofen and aspirin, severe dehydration, and exposure to toxic heavy metals can also cause insufficient kidney function, asserts Mayo Clinic. Medical conditions that prevent proper urination, such as kidney stones and blood clots in the urinary tract, can contribute to kidney problems. Any damage to the kidneys that inhibits their ability to properly filter toxins reduces their function, notes Healthline. Older people with a history of heart disease or heart failure, high blood pressure, diabetes or are otherwise hospitalized for a serious medical condition are at risk of developing acute renal failure, claims Mayo Clinic.

Although patients with acute renal failure can experience tiredness, nausea, chest pain and a significant decrease in urination, some patients may not experience any symptoms, states Mayo Clinic. Urine tests, blood tests and CT scans may be used to diagnose acute renal failure, but the condition can also be found by performing laboratory tests unrelated to a kidney disorder. Although acute renal failure can progress quickly and can be fatal, especially in hospitalized patients, insufficient kidney function can be effectively treated.