Can You Take Wellbutrin and Lexapro Together?


Quick Answer

Patients with major depressive disorder can safely take Lexapro and Wellbutrin together. An article in the Journal of Psychiatric Practice notes that the combination was both effective and well-tolerated in a group of 51 patients who had either chronic or recurrent non-psychotic major depressive disorder.

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Full Answer

The journal article clarifies that the combination of bupropion-SR (Wellbutrin) and the selective serotonin reuptake inhibitor (SSRI), escitalopram (Lexapro), is useful in treating patients who did not respond ideally to therapy with an SSRI alone. Psychiatrists treat most patients who have major depressive disorder solely with an SSRI, a practice that leads to depressive remission in around one third of patients.

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