Solid evidence does not exist to indicate that a vinegar soak cures toenail fungus. However, other home remedies, including the application of Vick's VapoRub, snakeroot extract or tea tree oil, may work, according to Mayo Clinic.
Ointments and creams containing antifungal medications provide topical solutions to combat toenail fungus, and they are available in both over-the-counter and prescription strength. Medicated nail cream and nail polish are alternative topical treatments, and they are available by prescription, reports Mayo Clinic.
Antifungal pills are also available and are the most successful at effectively treating toenail fungus, indicates WebMD. However, potential side effects include kidney and liver damage or failure and heart complications, which can lead to heart failure. Patients who use antifungal oral prescriptions are closely monitored by their physicians.