Naproxen and acetaminophen can be combined to treat pain, according to Everyday Health. Tylenol and generic acetaminophen are generally taken more often than naproxen. Patients can take acetaminophen in between doses of naproxen to spread out the pills over an entire day.Continue Reading
The reason both drugs can be taken during the same day is because naproxen and acetaminophen work differently. Naproxen is a nonsteroidal anti-inflammatory drug that reduces hormones that cause inflammation, notes Everyday Health. Acetaminophen reduces fever and relieves pain with maladies such as toothaches, headaches, colds and muscle aches.
It is important to follow directions on the labels of each drug, according to Everyday Health. Although no interactions between acetaminophen and naproxen are known, it doesn't mean no interactions exist, notes Drugs.com.
Naproxen may cause cardiovascular effects because it reduces inflammation, but this drug may have fewer cardiovascular effects than other NSAIDs, notes Harvard Medical School. Naproxen is also longer-acting than other NSAIDs, such as ibuprofen. Large amounts of acetaminophen cause liver damage, so it is important for patients to follow doctor's instructions and read warning labels. Aspirin is technically an NSAID, so patients who take aspirin should do so a few hours before naproxen. Both aspirin and naproxen bind themselves to the same chemical in the bloodstream, so naproxen may counteract aspirin, but the NSAID doesn't counteract acetaminophen.Learn more about Drug Interactions