Tylenol and Advil can be taken together, according to the Mayo Clinic. However, the Mayo Clinic advises people to avoid using these two medications together for more than a few days, unless directed to do so by a doctor.
Tylenol contains a common type of painkiller called acetaminophen, according to WebMD. Advil contains ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID), according to MedlinePlus. MedlinePlus explains that NSAIDs can have serious side effects, including gastro-intestinal bleeding, so it is important that patients avoiding exceeding the recommended dose. According to MedlinePlus and WebMD, because Tylenol and Advil can interact with a wide range of other medications, patients who are taking other medications should ask a doctor or pharmacist for advice before using either drug.