According to the CDC, there is no definitive scientific evidence to support the effectiveness of mayonnaise used to suffocate head lice. No evidence exists for the effectiveness of olive oil, margarine or butter to treat head lice either.
According to the CDC, most products used to effectively treat head lice are pesticides. Many head lice medications are available over-the-counter and include pyrethrins combined with piperonyl, and permethrin lotion. Some prescription medications to treat head lice include benzyl alcohol lotion, ivermectin lotion, malathion lotion and spinosad topical suspension. According to the Mayo Clinic, not all people are aware when they have a lice infestation. Common symptoms experienced may include itching, lice on scalp and lice eggs on hair shafts.