Treatment for an itchy rash on the legs depends on the diagnosis, according to DermNet. Possible diagnoses include a variety of types of dermatitis or eczema, psoriasis, cellulitis or various infections. Possible treatments include antibiotics or topical steroids, depending on the specific condition. DermNet also recommends treating dry skin with emollients and minimizing swelling by avoiding prolonged periods of standing.
University of Iowa Hospitals and Clinics recommends seeking the advice of a health care provider if a person is suffering from dermatitis or eczema. A range of treatments is available depending on the severity and location of the infection as well as the patient's age. National Health Services suggests use of a cold compress or calamine lotion to relieve itching. Other suggestions include avoiding tight-fitting clothing and using bed linen or clothing made with non-irritating fabrics.
According to MedicineNet, most rashes do not pose a health threat and resolve on their own. To relieve the discomfort associated with itchy rashes, over-the-counter anti-itch creams with hydrocortisone are sometimes effective, as are oral antihistamines. Moisturizing lotions are generally recommended. For fungal infections, MedicineNet recommends topical antifungal medications with clotrimazole, myconazole or terbinafine.
Diabetes often causes localized itching, particularly on the lower legs if poor circulation is the cause. The American Diabetes Association recommends limiting the number of baths taken and using mild, moisturizing cleanser as well as moisturizer.