Although most blisters heal on their own, certain treatments can help to relieve pain and prevent infection, explains WebMD. Home treatments for blisters include draining the blister and applying bandages and antibiotic ointment.
Small blisters don't need much care other than a loose bandage and reduced activity, states WebMD. For larger, more painful blisters, it may be necessary to drain the fluid using a needle or straight pin that has been sterilized with alcohol.
WebMD suggests first gently piercing the skin on the edge of the blister and then slowly pressing the fluid out of the blister toward where the hole was made. Because of the risk of infection, this treatment is not recommended for those with diabetes, HIV, cancer or heart disease.
For blisters that have already popped on their own, WebMD says to wash the blister with mild soap and water, avoiding chemicals such as alcohol and iodine. The site also suggests covering the blister with the remaining flap of skin, unless the skin is too damaged, dirty or infected. After cleaning the area, apply antibiotic ointment to the blister and cover it with a bandage. Make sure to keep the bandage clean and dry. Remove the bandage at night to let the blister dry out.