As of 2015, evidence suggests that probiotics are helpful in treating certain symptoms associated with Clostridium difficile, but not all probiotics provide the same effects, according to the National Institutes of Health. Scientists aren't sure which specific probiotics are beneficial, and antibiotics are most often an effective treatment.
Furthermore, patients with a severe infection may not have diarrhea when the colon is greatly inflamed, explains the National Institutes of Health. Complications can occur and may be life-threatening, causing issues such as toxic megacolon and severe bone or heart infections. The use of antibiotics is typically necessary, and in some cases, the condition requires more intensive treatment, such as surgery.