Pituitary disease can occur without pituitary tumors. Although rate, traumatic brain injuries and other disorders are also responsible for pituitary disease, according to the Pituitary Foundation.
Although most cases of pituitary disease occur due to benign tumors in or around the pituitary gland, the pituitary gland can also be damaged by radiation and surgery, leading to pituitary disease, explains eMedicineHealth. Infections around the brain and severe blood loss can also cause pituitary disease without the presence of a tumor, states the Pituitary Foundation.
Some disorders that can cause pituitary disease without causing tumors are diabetes insipidus, a disorder in which the kidneys cannot retain water; Kallmann's syndrome, a condition which inhibits the onset of puberty; septo-optic dysplasia, which inhibits development of the pituitary gland; Sheehan's syndrome, which causes the pituitary gland to stop functioning after a uterine hemorrhage during childbirth; empty sella syndrome, which causes the pituitary gland to decrease in size; sarcoidosis; and meningitis, which both can cause the pituitary gland to stop functioning properly, the Pituitary Foundation states.
Symptoms of pituitary disease can vary based on the type of condition, be it hormonal deficiencies due to hypopituitarism or pituitary tumors. Some symptoms include headaches, fatigue, loss of body hair, increased urination, changes in weight, nausea, vomiting, muscle weakness, irregular periods and low libido, according to Mayo Clinic.