According to the National Health Service of the United Kingdom, it is generally safe to take paracetamol while taking antibiotics. Some reports suggest a link between a higher risk of liver damage and the combination of paracetamol and isoniazid, however, so the NHS advises against giving the combination to children.
The NHS states that isoniazid is an antibiotic that doctors prescribe for tuberculosis. Paracetamol is among the safest painkillers, according to the NHS, but Drugs.com states that the drug, also known as acetaminophen, can cause serious liver damage if intake exceeds 4 grams per day. Drugs.com further advises that people who consume more than three alcoholic drinks per day should exercise caution in taking paracetamol.