Ibuprofen with penicillin do not interfere with each other and may be used safely in tandem, according to Dr. Scott Harwood on HealthTap. Ibuprofen is a non-steroidal drug used to treat pain, inflammation and fever, while the penicillin antibiotic combats bacterial infections, states Drugs.com.
Patients are typically prescribed 200 to 400 milligram doses of ibuprofen four to six times daily, not to exceed 2400 milligrams over a 24-hour period. Common side effects of stomach irritation and pain may be avoided by taking the medication with food.
Penicillin is often prescribed to patients in 500 milligram doses every four hours for up to 10 days. Side effects include rash and other allergic reactions, cite Hesperian Health Guides.