A person can safely take ibuprofen while drinking alcohol, according to Everyday Health; however, taking too much of both can cause stomach irritation and related problems. Alcohol irritates a person's stomach and intestinal tract, and extended use of ibuprofen can irritate the stomach and intestines.
Taking ibuprofen can also cause stomach ulcers and bleeding, reports Everyday Health. High dosages of ibuprofen in treating certain medical conditions can also cause gastrointestinal problems. The best strategy is to minimize alcohol consumption when taking any type of medication, but especially ibuprofen, and instead focus on using the medication to alleviate the health issue.