Most blisters can easily heal on their own, according to WebMD. When a blister is small and unbroken, place a bandage around it to prevent additional damage. Avoid the activity that caused the blister to speed its healing.
Draining some large blisters heals them more quickly, according to WebMD. To drain a blister, first clean a needle using rubbing alcohol. Then, puncture it and gently squeeze out the fluid. Clean the area using soap and water before applying a clean bandage to protect it. Use an antibiotic ointment on the blister to help prevent infection when the skin is broken.