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Can genetic disorders skip generations?

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Genetic disorders can skip generations when they are of the x-linked recessive diseases because the disease has to be inherited and then expressed, reports Correlagen Diagnostics, Inc. Females often carry the disease but do not express it and males, though they may express the disease, cannot pass the disease on to their sons because it exists in the x-chromosome.

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Can genetic disorders skip generations?
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Full Answer

The daughters of males who express and carry the disease will be affected because they must get their x-chromosome DNA from their father. These x-linked recessive diseases are able to bypass multiple generations when carried as a recessive gene. There are many different inherited patterns for genetic diseases, including autosomal dominant, autosomal recessive, x-linked dominant and codominant in addition to x-linked recessive, according to the U.S. National Institutes of Health. The autosomal recessive genetic disorder is the only other form of inheritance that can skip generations.

One example of an x-linked recessive disease is hemophilia. Hemophilia is a disorder that causes people difficulty with blood clotting and therefore they often bleed longer after surgical operations or injuries, states the National Human Genome Research Institute. This disease is inherited when parents pass on the x-chromosome to their children. For male children, there only needs to be one affected x-chromosome while female children need to have two affected x-chromosomes in order to have the disease.

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