Thumb and wrist pain may result from writer's cramps, carpal tunnel syndrome, tendinosis, de Quervain's disease and repetitive motion syndrome, according to WebMD. Trigger finger or thumb, gangilion cysts, and dupoytren's disease can also cause wrist and thumb pain. Additionally, injuries that lead to fractures or sprains can cause wrist and thumb pain.
Writer's cramps develop as a result of repeated finger or hand motions, which often occur when typing or writing, explains WebMD. Carpal tunnel syndrome is a common condition that puts pressure on the nerves in the wrist, leading to weakness, numbness and tingling of the fingers and hand. People with tendinosis have tears in the tissues near their tendons, and they struggle with decreased movement and strength in the wrists, hand or even thumbs. De Quervain's disease is a condition in which tendons on the portion of the wrist near the thumb become inflamed and swell. De Quervain's disease causes tenderness, pain and swelling in the hand, thumb, fingers or wrist.
Individuals with repetitive motion syndrome experience pain, tenderness and swelling in the wrist, thumb or hands after repetitive motion, according to WebMD. Trigger thumb or trigger finger causes the thumb and fingers to swell and thicken, whereas dupuytren's disease causes thickening of the tissues beneath the skin, which ultimately impairs movement. People with ganglion cysts have bumps filled with a jellylike clear fluid on their hands and wrists.