According to WebMD, red spots on the palms of the hands are a common symptom of psoriasis, a skin condition in which the skin cells rapidly multiply, resulting in plaques and patches on the skin. Red spots on the palms can also be caused by hand, foot and mouth disease or by endocarditis.
Psoriasis scales and patches are also found on the soles of the feet, knees, elbows and scalp, says WebMD. Psoriasis is caused by an abnormal immune response that can occur with stress or illness.
According to Kids Health, red spots on the palms of the hands are also a common symptom of hand, foot and mouth disease, a condition that occurs in children exposed to viruses in the enterovirus family. The viruses are spread via contact with unwashed hands and surfaces. The illness typically lasts three to five days.
According to Medline Plus, red spots on the palms can signify endocarditis, an inflammation of the lining of the heart valves and chambers. Endocarditis is typically caused by bacteria or fungi, but can also occur with no specific cause. Additional symptoms include fever, chills, sweating, painful red nodes on the pads of the fingers and bleeding under the fingernails. Treatment for endocarditis consists of long-term antibiotic therapy. In severe cases, individuals are treated with intravenous antibiotics.