Allergies, stress, excess moisture and exposure to chemicals, such as chromium and nickel, can trigger a rash on the fingers and toes, explains MedlinePlus. The condition is commonly referred to as dyshidrotic eczema, and flare-ups tend to occur periodically.
Treatments for dyshidrotic eczema include steroid topical ointments, oral antihistamine medications and nonsteroid prescription creams, explains Everyday Health. It is important for sufferers to do their best to avoid scratching the rash blisters, as this can cause the skin to thicken and hinder healing. The condition is known to recur and can cause secondary bacterial infections if left untreated. Keeping the skin lubricated and wearing protective gloves when working with chemicals can help to prevent recurrence.