What Can Cause IgG Kappa Monoclonal Protein to Appear in Blood Tests?

Monoclonal gammopathy is a condition that causes IgG kappa monoclonal protein to appear in blood tests, according to HealthTap doctors. Monoclonal gammopathy may develop into a more serious illness, including multiple myeloma and non-Hodgkin's lymphoma, notes University of Rochester Medical Center.

Monoclonal gammopathy describes conditions in which there are abnormal proteins in the blood, explains University of Rochester Medical Center. Doctors do not know what causes monoclonal gammopathy, but believe that factors such as infection, autoimmune conditions and the environment can contribute to its development. Patients with monoclonal gammopathy usually do not have symptoms, and the disease typically does not develop into a more serious condition, such as cancer.

Multiple myeloma is a form of cancer that affects plasma cells, according to Healthline. The condition causes a buildup of abnormal plasma cells in the bones, causing bone lesions. Multiple myeloma has no known cause, but risk factors that can lead to its development include being over 50, male and overweight. Patients with the cancer experience various symptoms, including constipation, kidney failure, fatigue and bone injuries.

Non-Hodgkin's lymphoma is cancer of the lymphatic system that has no known cause, notes Healthline. The cancer can be of two types, B-cell and T-cell, with B-cell lymphomas being more common than T-cell lymphomas. Risk factors for developing the disease include old age, the use of immunosuppressant drugs, and exposure to chemicals. Symptoms of non-Hodgkin's lymphoma include chest pain, fatigue, weight loss and swollen lymph nodes.