As of May 2015, Neo40 nitric oxide supplements are available for online purchase directly from maker Neogenis Labs on the company's website and through third-party sellers on Amazon.com. In November 2013, KENS5 Eyewitness News reported that the product was sold at compounding pharmacies as well as online.
In 2014, the National Advertising Division of the Advertising Self-Regulatory Council recommended that Neogenis stop making claims about Neo40 supplements' effect on users' blood pressure, circulation and bodily nitric oxide level and resultant effects on triglycerides, energy, endurance and sexual function, citing a lack of sufficient evidence, according to the Advertising Self-Regulatory Council. The decision came after the Council for Responsible Nutrition challenged the claims. Neogenis appealed, but in April 2015, the panel judging the appeal upheld the recommendation. Neogenis said it would adjust future advertising to reflect the recommendation, despite continued disagreement with the council's conclusions.