Blood pressure medicines can cause ankle swelling, according to Blood Pressure UK. This occurs when blood pressure medicine widens blood vessels and additional fluid passes through, collecting in tissues of the lower extremities. Calcium channel blockers are the most likely type of blood pressure medication to cause this condition.
Ankle swelling can become serious if left untreated over a long duration, notes Blood Pressure UK. Additional pressure on blood vessels and other tissues can induce cellulitis, venous ulcers and varicose veins. Patients who have ankle swelling from calcium channel blockers should reduce their dosages based on doctor's orders. In other cases, diuretics may be effective for reducing ankle swelling. It is best for patients with ankle swelling to keep their legs elevated when sitting.