A cold-sore sufferer should apply Abreva five times daily, or approximately once every three to four hours, until the affected cold sore heals, according to the website of the manufacturer, Abreva.com. Users should apply the cream to clean skin.
It is advisable to use fingertips or cotton swabs to apply Abreva to the affected area, as noted on Abreva.com. Users should apply an ample amount of cream to cover the sore and the area around it completely, rubbing the cream in gently. Abreva recommends using the product for no longer than 10 days and consulting a health care professional if treatment is not effective after 10 days of use.