Calamine lotions do not treat shingles, but they can ease the discomfort of a person who has it. Calamine lotion is most effective when applied to the skin after a cool and moist compress, according to WebMD.
Shingles rashes can be very itchy and painful. While there is no cure for shingles, calamine can be used to lessen the itchiness and pain. Calamine lotion has a soothing and cooling effect on the skin, which can help relieve skin itching, according to the National Health Service.
The main ingredient of calamine is zinc oxide, which has skin protecting and astringent properties, according to MedicineNet.com. Calamine and zinc oxide help prevent infections and slow down the growth of bacteria in skin rashes and blisters.