Bufferin is different from aspirin in that it contains aspirin and an antacid, such as calcium carbonate, magnesium oxide and aluminum hydroxide, as stated by WebMD. Aspirin can cause heartburn and a sour stomach, but the antacid in Bufferin helps counteract these side effects. The two drugs function in the same manner.
Both Bufferin and plain aspirin are used for the same purposes, including fever reduction, relieving mild pain and decreasing swelling. Aspirin is an anti-inflammatory drug that reduces inflammation in the body. It is useful for managing arthritis, muscle aches, headaches and toothaches.
Bufferin and aspirin can help prevent blood clots. They may also be used to decrease the likelihood of a heart attack or stroke.