Which Is Better: Cymbalta or Effexor?


Quick Answer

According to eMedExpert, both Cymbalta (duloxetine) and Effexor (venlafaxine) are similar in their effectiveness in the treatment of major depression and generalized anxiety disorder. Additionally, Effexor is approved to treat panic disorder and social anxiety disorder, while Cymbalta is not. Cymbalta is also effective for fibromyalgia and diabetic nerve pain.

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Full Answer

According to the Mayo Clinic, finding the best antidepressant for an individual patient is often a process of trial and error. Both Effexor and Cymbalta are serotonin and norepinephrine reuptake inhibitors (SNRIs). They are often used when the more common selective serotonin reuptake inhibitors (SSRIs) are not effective. Patients and their healthcare providers should also keep side effects and pre-existing conditions in mind when choosing the best antidepressant. For example, Effexor tends to raise blood pressure, while Cymbalta should not be taken by people with kidney or liver problems.

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