Some stated benefits of using Plexus Slim include weight loss and fat burning without losing muscle, according to the Plexus Slim website. Other reported benefits include healthy blood; healthy cholesterol and lipid levels; and increased willpower to prevent overeating.
The Plexus Slim website states that none of the alleged benefits of using Plexus Slim have been evaluated by the U.S. Food and Drug Administration. Dietpillswatchdog.com states there was one clinical study in 2008 that demonstrated that Plexus Slim may reduce glucose levels and cause weight loss. The 2008 study is not clinically referenced and has not been published in any journal.
Weightloss.com discourages the use of Plexus Slim, and states that the presence of polydextrose in Plexus Slim can cause unwanted side effects. R4ny.com states that some people reported several negative side effects, including nervousness, nausea, headache and dizziness.