Some evidence suggests using betel leaf may prevent oral cancers by maintaining ascorbic acid levels in the human mouth, according to the National Center for Biotechnology Information. As of 2015, there is little clinical research evidence to confirm benefits of betel leaf use by humans for detoxification and reduced inflammation.
For centuries, Chinese and Indian cultures have used betel leaves as folk remedies, notes the National Center for Biotechnology Information. Archaeological evidence shows people used the leaves as an antiseptic, a breath freshener and a stimulant. As of 2015, researchers have yet to conduct extensive studies to determine whether the properties of betel leaves can prevent cancer and diabetes.