Lotrimin is a commonly used over-the-counter antifungal cream used to treat fungal infections, although it does not treat itchiness as a symptom, states WebMD. Hydrocortisone cream may treat itching by itself, according to MedlinePlus. However, it does not treat underlying fungal infections.
Lotrimin and similar antifungal creams may take four weeks of regular use to show improvement of symptoms, according to WebMD. The cream should be used according to the label, which is usually twice daily application to clean, dry skin. Hydrocortisone may be applied for itching one to three times daily, says MedlinePlus. Always consult a doctor before combining over-the-counter medications, including Lotrimin and hydrocortisone.