What Is the Best Antibiotic for a Sinus Infection?


Quick Answer

Amoxicillin is a great choice for treating sinus infections and carries few side effects, according to WebMD. Patients that previously had mononucleosis should not take the drug; trimethoprim-sulfamethoxazole is often recommended to patients allergic to amoxicillin.

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Full Answer

The antibiotic works by killing and preventing the growth of bacteria in acute and chronic sinusitis to decrease inflammation, improve drainage and minimize discomfort, explain Everyday Health experts. Most patients recover quickly; the duration of treatment varies on the type of infection but is typically five to seven days in adults and 10 to 14 days for children.

If conditions do not improve within three to five days, a different antibiotic may be prescribed, cites WebMD.

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