A single pill of hydrocodone/APAP 10/325 milligrams is not the same as 1,000 milligrams of Vicodin. Both contain the same two medications: hydrocodone and acetaminophen, explains AbbVie. Vicodin 10/300 milligrams is the strength of Vicodin that is most similar to hydrocodone/APAP 10/325 milligrams, as both have 10 milligrams of hydrocodone.
Vicodin, Lortab, Norco and hydrocodone/APAP each contain different combinations of the same two ingredients. Vicodin comes in three strengths: Vicodin 5/300, Vicodin ES 7.5/300 and Vicodin HP 10/300, says Abbvie. The highest strength of Vicodin is Vicodin HP 10/300, which has 10 milligrams of hydrocodone and 300 milligrams of acetaminophen. Hydrocodone 1,000 milligrams is the equivalent to the amount of hydrocodone found in 10 Vicodin HP pills, an overdose according to the usual dosage instructions, indicates Drugs.com.