The city of Sikeston, Mo. was established in 1860, is centrally located between Saint Louis and Memphis, and is 25 miles from the Mississippi River. Sikeston has a mild climate, and rice, corn, wheat, soybeans, potatoes and melons are some of the fruit and vegetables that are produced commercially in this area. Historic downtown Sikeston has had a makeover and now sports cobblestone streets, period lighting, specialty stores and boutiques,
With 281 acres of parks, Sikeston provides residents with numerous recreational opportunities such as lakes for fishing, trails for walking, biking and running, floodlit tennis and basketball courts, and soccer, baseball, football and softball fields. The Missouri Delta Medical Center, with more than 185 beds and 84 physicians on the medical staff, was voted number one in the state for overall patient experience in a 2014 survey.
Some of the attractions to be explored by visitors to Sikeston, Mo., include the Sikeston Depot Cultural Center and Museum, the Southeast Missouri Agricultural Museum and Granny Antiques, and the El Camino Real Historic Marker. A driving tour of the more than 24 imposing millionaires' homes that were constructed in the early 1900s, when Sikeston had more millionaires per capita than any other city of its size in the United States, is also available to visitors.