There are 76 exits while traveling northbound on I-65 through Indiana and 78 exits while traveling southbound. Those exits are located within the 261.27 miles covered by I-65 in the state of Indiana.
The Indiana portion of I-65 has been in existence since 1956. The southern end of I-65 in Indiana begins after crossing over the Ohio River from Louisville, Kentucky by way of the John F. Kennedy Memorial Bridge. It then travels through several of Indiana's biggest cities, including the capital city of Indianapolis. The northern terminus of I-65 is in Gary, Indiana, where the interstate combines with United States Highways 12 and 20.