The longest river in South America is the Amazon River at a total length of 4,049 miles. Only the Nile River in Africa is longer at a total of 4,160 miles. However, the Amazon River's discharge of over 7.3 million cubic feet per second is greater than the Nile's discharge.
The Amazon River reaches a maximum width of about 120 miles during the wet season, while the Nile River reaches a width of only 2 miles. The Amazon River flows through the South America countries of Guyana, Ecuador, Venezuela, Bolivia, Brazil, Colombia and Peru. The largest city that the Amazon River runs along is Manaus, Brazil.