Interjet primarily serves cities in Mexico and the United States, although it also travels to other major cities in the western hemisphere. Interjet's hubs are located in Mexico City and Toluca.
Interjet flights to and from the United States primarily use Mexico City as the hub. U.S. destinations include John F. Kennedy International Airport in New York City, Miami International Airport, and George Bush Intercontinental Airport in Houston. Toluca's only U.S. connection is McCarran International Airport in Las Vegas. Interjet serves other destinations in Central and South America. From Mexico City, flights go to Guatemala City, San Jose in Costa Rica, Havana in Cuba and Bogotá, Colombia.
Interjet's primary advantage over other international airlines is that it serves as a connection to many smaller Mexican cities. There are flights to common tourist destinations, such as Puerto Vallarta, Acapulco, Meridá and Cancún. There are also flights to major border cities, including Tijuana, Reynosa, and Chetumal. Interjet also serves some of Mexico's most-populated cities, which include Guadalajara, Ciudad Juárez, and León.
In northern Mexico, smaller destinations served by Interjet include Monterrey, Chihuahua, Hermosillo, and Torreón. In southern Mexico, towns such as Oaxaca and Zihuatanejo also receive Interjet flights. La Paz and Los Cabos in Baja California are also Interjet destinations.