To get to Yosemite from the Fresno Airport, the first step is to get on CA-180 W and drive 1.9 miles. Next, merge onto CA-41 N/ Hwy 41-N, continuing as it becomes CA-41 N, and travel another 46.8 miles to Yosemite. There are other driving options, as well.
The total distance from the Fresno Airport to Yosemite is 64.7 miles using the aforementioned route, and takes approximately 1 hour and 18 minutes without traffic, according to Google Maps. It is important to know that once you have passed through the town of Oakhurst, there is not much in the way of services, as the rest of the trip is mostly through the mountains.
Another option is to take Willow Avenue for 9 miles before making a right and traveling on N. Friant Road for 5.2 miles, followed by a 42.4 mile drive on CA-41 N. This route also is 64.7 miles, but takes approximately 1 hour and 28 minutes without traffic.
If you prefer not to drive, there are public transportation options to get to Yosemite. The Yosemite Area Regional Transit System (YARTS) runs year-round and takes approximately four hours from Fresno Airport to Yosemite. Round trip tickets can range anywhere from $20 to $30, as of 2015.