The shortest route between Orlando-Sanford International Airport and Walt Disney World Resort uses Interstate 4 West as of 2015. An alternative route between the two destinations uses several Florida state routes with tolls.
Using the I-4 route, the first direction upon leaving the airport is to head west on East Airport Boulevard. Then, take a left on Mellonville Avenue and a right on East Lake Mary Boulevard. After passing North Ronald Reagan Boulevard, take the ramp onto State Route 417 North. Take Exit 55B, which merges onto I-4 West. Then, take Exit 67, and merge onto Epcot Center Drive, which is one of the main entrances to Walt Disney World.
To use the alternate route, pass Mellonville Avenue and continue west on East Airport Avenue. Then, turn left, and merge onto the ramp that leads to State Route 417 South. Take Exit 6, and drive straight onto World Center Drive, which turns into Epcot Center Drive.
A third possible route is taking State Route 417 South and getting off on Exit 26. This exit ramp merges onto State Route 528 West. At the expressway's end, stay in the left lane to merge onto I-4 West until reaching Exit 64.
Exit 67 on I-4 gives direct access to Epcot and Downtown Disney. However, Exit 65 gives easier access to Animal Kingdom. Disney recommends Exit 64 for visitors heading to Magic Kingdom.