Some important cities on a map of the Ohio River are Pittsburgh, Pennsylvania; Cincinnati, Ohio; Louisville, Kentucky; Huntington, West Virginia; and Evansville, Indiana. Other notable places along the Ohio River are the West Virginia cities of Parkersburg, Wheeling and Weirton, as well as the Kentucky city of Owensboro.
The Ohio River begins in Pittsburgh. From there, the river flows north by the Pennsylvania towns of Sewickley, Coraopolis, Ambridge and Aliquippa. At the town of Rochester, the Ohio River turns west. The river then passes by the towns of Beaver and Midland before reaching Pennsylvania's border with the state of Ohio.
Upon passing the Ohio city of East Liverpool, the river turns south. The river's route defines Ohio's border with West Virginia. Cities on the Ohio side of the river include Steubenville, Martins Ferry, Marietta and Gallipolis. Cities on the West Virginia side of the river include Wheeling, New Martinsville, Parkersburg, Point Pleasant and Huntington.
Around the Ohio city of Ironton, the Ohio River begins to define the border between the states of Ohio and Kentucky. Some Kentucky cities across the border from Ohio include Ashland, Vanceburg, Maysville, Brooksville and Newport. After the river passes Cincinnati, the river begins to define Kentucky's border with Indiana. After passing the Indiana town of Mount Wilson, the Ohio River defines Kentucky's border with Illinois. The Ohio River empties into the Mississippi River at Cairo, Illinois.