The Food and Drug Administration suggests that an individual should not consume more than 5 milligrams of sucralose per kilogram of body weight per day. Otherwise, the FDA approves of it for use as a non-nutritive sweetener.
Sucralose, which is also known by the brand name Splenda, potentially shrinks the thymus prematurely, causes leukemia and damages DNA and may also spike blood sugar levels. In 2013, the Center for Science in the Public Interest downgraded sucralose from safe to caution.
Dr. Morando Soffritti and his team at the Ramazzini Institute in Bologna, Italy, led a study that saw a link between the consumption of sucralose and leukemia in rats. The study began in 2012, and Dr. Soffritti shared his preliminary findings early on, but he has not officially published the full results of his study in a recognized journal, as of 2015.
A 2014 study at Tufts University uncovered the correlation between sucralose and blood sugar. High amounts of sucralose affect certain strains of digestive bacteria present in the intestines, and the result is an impaired ability of the body to metabolise sugar effectively. Findings from this study first appeared in an online edition of the journal The Proceedings of the National Academy of Sciences. Details of the study revealed that mice used as subjects were nearly diabetic prior to ingesting sucralose, and a team of scientists fed them extraordinarily high amounts of sucralose in the form of a simple syrup. In some cases this was the equivalent amount of four cans of diet soda.