Cook pork roast until it reaches an internal temperature of at least 145 degrees Fahrenheit. This may take 20 minutes per pound in a 350 degree oven.
Check meat temperatures with a digital food thermometer. After finished, allow the pork roast to rest for three minutes before cutting it. After being cut, the pork roast may have a pink tinge in the middle, but it is safe to eat. Cooking temperature and ingredients may cause the pink coloring. Although a pork roast can be safely cooked to 145 degrees Fahrenheit, cook ground pork and organs such as liver and chitterlings to at least 160 degrees Fahrenheit.