The Food and Drug administration approved Splenda, suggesting it is safe for use as a sweetener. Although Splenda is safe for consumption, a study published on PubMed Central suggests adverse affects on some of the body's biological functions.
Concerns are raised about Splenda because it reduces some the good bacteria found in the stomach and intestines, explains Prevention. It also alters the body's response to insulin and fluctuates blood sugar levels. Research has also shown that Splenda makes some medications less effective.
The American Heart Association suggests using regular sugar in moderation to avoid the potential harmful affects of Splenda and other artificial sweeteners, as reported by Prevention.