To make a simple but flavorful grilled grouper, place grouper fillets in a shallow baking dish and season them to taste with dry seasonings or a marinade. Let the fish sit in the refrigerator for 20 to 30 minutes, covered, to absorb the flavors. Preheat the grill to medium-high heat. Clean and coat the grates with cooking spray and grill the fish for approximately four to five minutes per side, or until the fish is flaky and opaque.
Grouper has a firm texture that stands up to the heat of the grill, and a mild, sweet flavor that can stand on its own seasoned simply with salt and pepper, or paired with bolder flavors. To make a spicy marinade, combine 1/4 cup lemon juice with 1 1/2 teaspoons chili powder, 1/4 teaspoon cumin and 1/4 teaspoon paprika. Stir in minced garlic and cayenne pepper to taste.
Alternatively, give the grouper spicy kick with a dry rub inspired by blackening spices. Combine 1 tablespoon of paprika with 1 tablespoon dried oregano and 1 tablespoon dried thyme. Stir in 1 teaspoon white pepper, 1 teaspoon black pepper and 1 teaspoon garlic powder. Prepare the fish by patting it dry, brushing it with melted butter and evenly applying the blackening rub before placing the fish on the grill.
Yet another option is to serve grilled grouper with a tasty topping. Make a cool but spicy watermelon salsa by combining 2 cups of chopped watermelon with chopped English cucumber and 1 minced jalapeño pepper. Stir in 2 tablespoons minced red onion, 2 tablespoons white balsamic vinegar and 1 tablespoon olive oil. Allow the mixture to stand for a short time before using it to top the fish.